Trial match report
Weighted eligibility scoring · 3 matched trials · mCRPC · Panel: VE-104-GU
VE
Patient ID: VE-2024-0042
Rank #1
NCT05551364
Olaparib + Pembrolizumab — ATM/CDK12 mCRPC
Phase II · mCRPC · HRR-mutant · 11 sites
88
Fit score / 100
ATM LOF (c.7630+1G>A) — primary trial target mutation
+20pts
CDK12 biallelic LOF — co-mutation enrichment arm
+14pts
Prior abiraterone — satisfies prior NHA requirement
+12pts
PSA 34.2 — above 20 threshold, waiver pathway available
−8pts
Rank #2
NCT05009082
Rucaparib Maintenance — Post-Docetaxel mCRPC
Phase III · mCRPC · HRR+ · 19 sites
74
Fit score / 100
ATM LOF — meets HRR-positive definition
+16pts
Prior docetaxel — maintenance eligibility met
+14pts
CDK12 — not in primary HRR gene list; partial credit
−6pts
Nearest site 34 miles — travel burden flag
−4pts
Rank #3
NCT04921371
FGFR3 Inhibitor — Biomarker Expansion Cohort
Phase II · mCRPC · FGFR/CDK12 · 7 sites
61
Fit score / 100
CDK12 biallelic LOF — expansion cohort biomarker
+14pts
No FGFR3 alteration detected — partial cohort eligibility
−12pts
ECOG 1 — within performance status window
+10pts
Enrollment window closing — 6 slots remaining
−6pts
Score factor breakdown — NCT05551364 (Top trial)
Weighted model · 100 pts · Click to expand · Double-click to override
ATM loss-of-function mutation
c.7630+1G>A splice site — primary HRR target
20 / 20
Weight: 20%
CDK12 biallelic inactivation
Biallelic LOF — co-mutation enrichment arm eligibility
14 / 15
Weight: 15%
Prior NHA therapy
Prior abiraterone confirmed — satisfies 2nd-line requirement
15 / 15
Weight: 15%
ECOG performance status
ECOG 1 — optimal for combination regimen
10 / 10
Weight: 10%
PSA level at screening
34.2 ng/mL — above 20 threshold; waiver pathway available
5 / 10
Weight: 10%
Enrollment slot availability
38 slots remaining · enrollment window open Q3 2026
12 / 15
Weight: 15%
No prior PARP inhibitor exposure
PARP-naive — maximum benefit population per protocol
5 / 5
Weight: 5%
Organ function — hepatic/renal
ALT 1.4× ULN · Cr 1.1 — within protocol thresholds
7 / 10
Weight: 10%